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Renal underexcretion gout

ABCG2 · rs1871744

Where this position leads

Condition: Gout

Drug: Statins

rs1871744 Condition: Gout Gout Condition Drug: Statins Statins Drug rs1871744 rs1871744 ABCG2

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Renal underexcretion gout — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Renal underexcretion gout.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Renal underexcretion gout compared to the general population.
Source
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes
Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T
and 34 more — show all
Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N, Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H
Eurogout Consortium · Eurogout Consortium
Annals of the rheumatic diseases · 2017 · PMID 27899376 · open access

Questions about rs1871744

What is rs1871744?

rs1871744 is a single position in the genome, in or near the ABCG2 gene. Published research associates it with renal underexcretion gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1871744 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does rs1871744 affect how medicines work?

ABCG2 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs1871744 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1871744 come from?

GWAS Catalog, Ann Rheum Dis 2016, PMID:27899376. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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