Plasma metabolonic lactone sulfate levels in chronic kidney disease
SLCO1B1 · rs1871395
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Who was studied 4,811 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.464 higher (95% confidence interval 0.41-0.52); p = 3 × 10−58.
How common The G allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
A/ANo copy of the version the research linked to Plasma metabolonic lactone sulfate levels in chronic kidney disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Plasma metabolonic lactone sulfate levels in chronic kidney disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Plasma metabolonic lactone sulfate levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs1871395
What is rs1871395?
rs1871395 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with plasma metabolonic lactone sulfate levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs1871395 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs1871395 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1871395 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 411128122321Reads by AI crawlersClaude1ChatGPT1Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others21Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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