Gene Knowledge Graph
UTC
Standard

Hemorrhage from gastrointestinal ulcer (PheCode 531.1)

near LINC01254 · rs184829320

Where this position leads

Condition: Hemorrhage from Gastrointestinal Ulcer

rs184829320 Condition: Hemorrhage from Gastrointestinal Ulcer Hemorrhage from Gastrointestinal Ulcer Condition rs184829320 rs184829320 near LINC012…

What the study found

Who was studied 594 African American or Afro-Caribbean cases, 120,387 African American or Afro-Caribbean controls, 2,163 European ancestry cases, 446,114 European ancestry controls, 255 Hispanic or Latin American cases, 59,281 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 2.87 lower (95% confidence interval 2.83-2.9); p = 4 × 10−11.

How common The A allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 18, band 18p11.22 — between genes, 66 kb from LINC01254.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hemorrhage from gastrointestinal ulcer (PheCode 531.1) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hemorrhage from gastrointestinal ulcer (PheCode 531.1).
G/G Published research associates this genotype with typical/baseline likelihood of Hemorrhage from gastrointestinal ulcer (PheCode 531.1) — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs184829320

What is rs184829320?

rs184829320 is a single position in the genome, in or near the near LINC01254 gene. Published research associates it with hemorrhage from gastrointestinal ulcer (phecode 531.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs184829320 linked to?

On MyGeneLog this position is linked to Hemorrhage from Gastrointestinal Ulcer. The research behind each link, and its sources, are set out on that condition page.

Does having rs184829320 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs184829320 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hemorrhage from gastrointestinal ulcer (PheCode 531.1) (rs184829320). MyGeneLog™. https://www.mygenelog.com/variants/rs184829320

← See all variants