Hemorrhage from Gastrointestinal Ulcer, as genome-wide studies have reported it: 11 positions from 1 study, the largest recording 3,012 cases and 625,782 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
This is the record of what genome-wide association studies have found for Hemorrhage from Gastrointestinal Ulcer (the GWAS Catalog's "Hemorrhage from gastrointestinal ulcer (PheCode 531.1)"): 11 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 3,012 cases and 625,782 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 11 positions: rs183178550 (KCNJ5-AS1), rs147504619 (near NPEPPSP1), rs76036799 (near IRF4), rs542975891 (LINC03109), rs544767983 (near L3MBTL3), rs552964187 (LRRK2), rs189578345 (near AK6P2), rs545934910 (near MRPS33P3), and 3 more. PMID:39024449.
The catalogue maps the 11 positions to 11 genes: KCNJ5-AS1, NPEPPSP1, IRF4, LINC03109, L3MBTL3, LRRK2, AK6P2, MRPS33P3, YPEL5, LINC01951, LINC01254. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Verma A et al. 2024 reported the smallest P value on this page — P = 4 × 10-13 — at rs183178550 in KCNJ5-AS1.
It is a record of what genome-wide studies have reported about Hemorrhage from Gastrointestinal Ulcer, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Hemorrhage from Gastrointestinal Ulcer; a clinician does. No guideline uses the 11 variants on this page to predict it, screen for it or confirm it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Hemorrhage from Gastrointestinal Ulcer comes down to these specific, well-studied positions — not a diagnosis.
KCNJ5-AS1 · rs183178550
See detailed info →near NPEPPSP1 · rs147504619
See detailed info →near IRF4 · rs76036799
See detailed info →LINC03109 · rs542975891
See detailed info →near L3MBTL3 · rs544767983
See detailed info →LRRK2 · rs552964187
See detailed info →near AK6P2 · rs189578345
See detailed info →near MRPS33P3 · rs545934910
See detailed info →near YPEL5 · rs529776754
See detailed info →near LINC01951 · rs767453489
See detailed info →near LINC01254 · rs184829320
See detailed info →Databases, guidelines and references
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Hemorrhage from Gastrointestinal Ulcer. MyGeneLog™. https://www.mygenelog.com/conditions/hemorrhage-from-gastrointestinal-ulcer
Hemorrhage from Gastrointestinal Ulcer is the condition the GWAS Catalog files under "Hemorrhage from gastrointestinal ulcer (PheCode 531.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 11 positions from 1 study, with each study's sample and citation.
Genes play a part: 11 positions have been linked to it, the largest study recording 3,012 cases and 625,782 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 11 genes: KCNJ5-AS1, NPEPPSP1, IRF4, LINC03109, L3MBTL3, LRRK2, AK6P2, MRPS33P3, YPEL5, LINC01951, LINC01254. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Hemorrhage from Gastrointestinal Ulcer is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.