Gene Knowledge Graph
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Sensitive

Rotor syndrome

SLCO1B1 · rs183501729

Where this position leads

Drugs: Statins, Ticagrelor

rs183501729 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs183501729 rs183501729 SLCO1B1

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Rotor syndrome, SLCO1B1-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2025-11-03. ClinVar record 30439 NM_006446.5(SLCO1B1):c.757C>T (p.Arg253Ter)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version ClinVar lists as disease-causing for Rotor syndrome. This is the usual result. (ClinVar VCV000030439, criteria provided, multiple submitters, no conflicts)
C/T One copy of the version ClinVar lists as disease-causing for Rotor syndrome. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000030439, criteria provided, multiple submitters, no conflicts)
T/T Two copies of the version ClinVar lists as disease-causing for Rotor syndrome. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000030439, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV000030439, criteria provided, multiple submitters, no conflicts

Questions about rs183501729

What is rs183501729?

rs183501729 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with rotor syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs183501729 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs183501729 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs183501729 come from?

ClinVar VCV000030439, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Rotor syndrome (rs183501729). MyGeneLog™. https://www.mygenelog.com/variants/rs183501729

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