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Who was studied 3,376 European ancestry cases, 15,151 European ancestry controls, 1,516 East Asian ancestry cases, 32,649 East Asian ancestry controls, 252 Sub-Saharan African ancestry cases, 197 Sub-Saharan African ancestry controls.
The effect
Each copy of the T allele carried 1.20 times the odds of Glaucoma (high intraocular pressure) (95% confidence interval 1.14-1.26); p = 1 × 10−9.
Where it sits Chromosome 11, band 11q23.3 — in an intron of ARHGEF12.
What each result means
C/CNo copy of the version the research linked to Glaucoma (high intraocular pressure). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Glaucoma (high intraocular pressure). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (high intraocular pressure). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33627673 · open access
Questions about rs1812974
What is rs1812974?
rs1812974 is a single position in the genome, in or near the ARHGEF12 gene. Published research associates it with glaucoma (high intraocular pressure). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1812974 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1812974 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1812974 come from?
GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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