Sensitive

Type 2 diabetes

MYO5C · rs17650541

Where this position leads

Condition: Type 2 Diabetes

rs17650541 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs17650541 rs17650541 MYO5C

What the study found

Who was studied 2,765 Qatari ancestry cases, 8,671 Qatari ancestry controls, 180,834 European ancestry cases, 1,159,055 European ancestry controls, 180,834 East Asian ancestry cases, 1,159,055 East Asian ancestry controls, 180,834 South Asian ancestry cases, 1,159,055 South Asian ancestry controls, 180,834 African ancestry cases, 1,159,055 African ancestry controls, 180,834 Hispanic or Latin American cases, 1,159,055 Hispanic or Latin American controls.

The effect Each copy of the G allele shifted the measure 0.0434 lower (95% confidence interval 0.029-0.057); p = 8 × 10−10.

Where it sits Chromosome 15, band 15q21.2 — in an intron of MYO5C.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Type 2 diabetes — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 diabetes.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 diabetes compared to the general population.
Source

Questions about rs17650541

What is rs17650541?

rs17650541 is a single position in the genome, in or near the MYO5C gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17650541 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs17650541 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17650541 come from?

GWAS Catalog, BMC medical genomics 2024, PMID:38685053. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Type 2 diabetes (rs17650541). MyGeneLog™. https://www.mygenelog.com/variants/rs17650541

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