Standard

Heart failure

BAG3 · rs17617337

Where this position leads

What the study found

Who was studied 5,791 African ancestry cases, 20,883 African ancestry controls, 1,170 American ancestry cases, 13,217 American ancestry controls, 95,524 European ancestry cases, 1,270,968 European ancestry controls, 17,718 East Asian ancestry cases, 247,144 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0407 lower (95% confidence interval 0.028-0.054); p = 9 × 10⁻¹⁰.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 10, band 10q26.11 — in an intron of BAG3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Heart failure — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart failure.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart failure compared to the general population.

Source

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K

and 18 more — show all

Onouchi Y, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K

BioBank Japan Project

Nature communications · 2025 · PMID 41184235 · open access

Questions about rs17617337

What is rs17617337?

rs17617337 is a single position in the genome, in or near the BAG3 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17617337 linked to?

On MyGeneLog this position is linked to Heart Failure Progression. The research behind each link, and its sources, are set out on that condition page.

Does having rs17617337 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17617337 come from?

GWAS Catalog, Nature communications 2025, PMID:41184235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (rs17617337). MyGeneLog™. https://www.mygenelog.com/variants/rs17617337

← See all variants