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Chronotype

DPYD · rs1760217

Where this position leads

Drug: Fluoropyrimidines

rs1760217 Drug: Fluoropyrimidines Fluoropyrimidines Drug rs1760217 rs1760217 DPYD

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0142 higher (95% confidence interval 0.01-0.018); p = 2 × 10−11.

How common The A allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.

What each result means

A/A Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
G/G No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
Source
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H
and 20 more — show all
Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN
Nature communications · 2019 · PMID 30696823 · open access

Questions about rs1760217

What is rs1760217?

rs1760217 is a single position in the genome, in or near the DPYD gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs1760217 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs1760217 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1760217 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronotype (rs1760217). MyGeneLog™. https://www.mygenelog.com/variants/rs1760217

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