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Who was studied 1,748 European ancestry cases, 2,938 European ancestry controls; replicated in (see Parkes 2007).
The effect
Each copy of the G allele carried 1.54 times the odds of Crohn's disease (95% confidence interval 1.34-1.76); p = 2 × 10−12.
How common The G allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 5, band 5p13.1 — between genes, 11.6 kb from LOC124900967.
What each result means
G/GTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs17234657 is a single position in the genome, in or near the near TTC33 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17234657 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs17234657 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17234657 come from?
GWAS Catalog, Nature 2007, PMID:17554300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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