Sensitive

Type 2 diabetes

DEPDC5 · rs16989540

Where this position leads

What the study found

Who was studied 23,541 Hispanic or Latino cases, 37,434 Hispanic or Latino controls.

The effect Each copy of the C allele carried 0.86 times the odds of Type 2 diabetes (95% confidence interval 0.82-0.91); p = 1 × 10⁻¹¹.

How common The C allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 22, band 22q12.3 — in an intron of DEPDC5.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

T/T No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

Source

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Petty LE, Chen HH, Frankel EG, Zhu W, Downie CG, Graff M, Lin P, Sharma P, Zhang X, Scartozzi AC, Roshani R, Landman JM

and 80 more — show all

Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Sim X, Spracklen CN, Zhang W, Preuss M, Bottinger EP, Nadkarni GN, Loos RJF, Chen YI, Tan J, Ipp E, Genter P, Emery LS, Louie T, Sofer T, Stilp AM, Taylor KD, Xiang AH, Buchanan TA, Roll K, Gao C, Palmer ND, Norris JM, Wagenknecht LE, Nousome D, Varma R, McKean-Cowdin R, Guo X, Hai Y, Hsueh W, Sandow K, Parra EJ, Cruz M, Valladares-Salgado A, Wacher-Rodarte N, Rotter JI, Goodarzi MO, Rich SS, Bertoni A, Raffel LJ, Nadler JL, Kandeel FR, Duggirala R, Blangero J, Lehman DM, DeFronzo RA, Thameem F, Wang Y, Gahagan S, Blanco E, Burrows R, Huerta-Chagoya A, Florez JC, Tusie-Luna T, González-Villalpando C, Orozco L, Haiman CA, Hanis CL, Rohde R, Whitsel EA, Reiner AP, Kooperberg C, Li Y, Duan Q, Lee M, Correa-Burrows P, Fried SK, North KE, McCormick JB, Fisher-Hoch SP, Gamazon ER, Morris AP, Mercader JM, Highland HM, Below JE

DIAMANTE Hispanic/Latino Consortium · Global Hispanic Lipids Consortium

Nature communications · 2025 · PMID 40210677 · open access

Questions about rs16989540

What is rs16989540?

rs16989540 is a single position in the genome, in or near the DEPDC5 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16989540 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs16989540 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16989540 come from?

GWAS Catalog, Nature communications 2025, PMID:40210677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs16989540). MyGeneLog™. https://www.mygenelog.com/variants/rs16989540

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