HORMAD2 · rs16988333
Where this position leads
Condition: Type 2 Diabetes
What the study found
Who was studied 61,714 European ancestry cases, 1,178 Pakistani ancestry cases, 593,952 European ancestry controls, 2,472 Pakistani ancestry controls.
The effect Each copy of the G allele shifted the measure 0.0745 lower (95% confidence interval 0.049-0.1); p = 9 × 10−9.
How common The G allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 22, band 22q12.2 — in an intron of HORMAD2.
rs16988333 is a single position in the genome, in or near the HORMAD2 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2018, PMID:30054458. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.