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Depression

CACNA1E · rs169235

Where this position leads

Conditions: Depression (Self-Reported Symptoms), Post-Traumatic Stress Disorder (PTSD)

rs169235 Condition: Depression (Self-Reported Symptoms) Depression (Self-Reported Symptoms) Condition Condition: Post-Traumatic Stress Disorder (PTSD) Post-Traumatic Stress Disorder (PTSD) Condition rs169235 rs169235 CACNA1E

What the study found

Who was studied 118,811 European ancestry cases, 327,427 European ancestry controls, 127,552 cases, 233,763 controls; replicated in 414,055 European ancestry cases, 892,299 European ancestry controls.

The effect Each copy of the G allele carried 1.02 times the odds of Depression (95% confidence interval 1.01-1.02); p = 2 × 10−11.

How common The G allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 1, band 1q25.3 — in an intron of CACNA1E.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-02-28. ClinVar record 1253077 NM_001205293.3(CACNA1E):c.4974-278A>G

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
Source
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X
and 26 more — show all
Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA, Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM
23andMe Research Team · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nature neuroscience · 2019 · PMID 30718901

Questions about rs169235

What is rs169235?

rs169235 is a single position in the genome, in or near the CACNA1E gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs169235 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms), Post-Traumatic Stress Disorder (PTSD). The research behind each link, and its sources, are set out on that condition page.

Does having rs169235 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs169235 come from?

GWAS Catalog, Nat Neurosci 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Depression (rs169235). MyGeneLog™. https://www.mygenelog.com/variants/rs169235

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