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Who was studied 254,641 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0244 lower (95% confidence interval 0.017-0.032); p = 4 × 10−11.
How common The C allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 12.7 kb from HLA-B.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fluid intelligence score (baseline) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fluid intelligence score (baseline).
T/TPublished research associates this genotype with typical/baseline likelihood of Fluid intelligence score (baseline) — no copies of the reported risk allele.
Nature communications · 2025 · PMID 40374629 · open access
Questions about rs1634776
What is rs1634776?
rs1634776 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with fluid intelligence score (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1634776 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs1634776 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1634776 come from?
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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