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Monocyte count

near HLA-B · rs1634774

Where this position leads

Conditions: Blood Cell Counts, Monocyte Count

rs1634774 Condition: Blood Cell Counts Blood Cell Counts Condition Condition: Monocyte Count Monocyte Count Condition rs1634774 rs1634774 near HLA-B

What the study found

Who was studied 234,690 European ancestry individuals; replicated in 100,494 European ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−34.

How common The A allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 18.4 kb from HLA-B.

What each result means

A/A Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
G/G No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
Source

Questions about rs1634774

What is rs1634774?

rs1634774 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1634774 linked to?

On MyGeneLog this position is linked to Blood Cell Counts, Monocyte Count. The research behind each link, and its sources, are set out on that condition page.

Does having rs1634774 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1634774 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Monocyte count (rs1634774). MyGeneLog™. https://www.mygenelog.com/variants/rs1634774

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