MAP3K15 · rs15943
Where this position leads
Condition: Type 2 Diabetes
What the study found
Who was studied 51,256 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 370,487 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls; replicated in 73,088 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 79,827 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls.
The effect Each copy of the C allele shifted the measure 0.259 lower (95% confidence interval 0.18-0.34); p = 8 × 10−11.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome X, band Xp22.12 — a missense change in MAP3K15.
What ClinVar records
Classification
Benign for Pyruvate dehydrogenase E1-alpha deficiency, MAP3K15-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2018-01-12.
ClinVar record 376916 NM_000284.4(PDHA1):c.*1869G>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs15943 is a single position in the genome, in or near the MAP3K15 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2024, PMID:39379762. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs15943). MyGeneLog™. https://www.mygenelog.com/variants/rs15943