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Vertical cup-disc ratio

CHEK2 · rs1547014

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Vertical cup-disc ratio — no copies of the reported risk allele. (GWAS Catalog, PLoS Genet 2010, PMID:20548946)

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vertical cup-disc ratio. (GWAS Catalog, PLoS Genet 2010, PMID:20548946)

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vertical cup-disc ratio compared to the general population. (GWAS Catalog, PLoS Genet 2010, PMID:20548946)

Source: GWAS Catalog, PLoS Genet 2010, PMID:20548946

Questions about rs1547014

What is rs1547014?

rs1547014 is a single position in the genome, in or near the CHEK2 gene. Published research associates it with vertical cup-disc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1547014 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1547014 come from?

GWAS Catalog, PLoS Genet 2010, PMID:20548946. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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