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Who was studied 521,594 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.013 SD unit higher (95% confidence interval 0.0091-0.0168); p = 4 × 10−11.
How common The G allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 1, band 1p35.2 — between genes, 16.6 kb from MATN1.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Monocyte count — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Monocyte count.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Monocyte count compared to the general population.
rs1535770 is a single position in the genome, in or near the near MATN1 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1535770 linked to?
On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.
Does having rs1535770 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1535770 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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