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Who was studied 148,726 European ancestry cases, 965,732 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0994 lower (95% confidence interval 0.077-0.121); p = 7 × 10−19.
How common The G allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 4, band 4p16.3 — in an intron of PCGF3.
What each result means
G/GTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2020 · PMID 32541925 · open access
Questions about rs1531583
What is rs1531583?
rs1531583 is a single position in the genome, in or near the PCGF3 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1531583 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs1531583 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1531583 come from?
GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs1531583). MyGeneLog™. https://www.mygenelog.com/variants/rs1531583