2 392215112223Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot1Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 5,333 European ancestry cases, 12,019 European ancestry controls; replicated in 7,053 cases, 9,007 controls.
The effect
Each copy of the G allele carried 1.27 times the odds of Parkinson's disease (95% confidence interval 1.21-1.33); p = 6 × 10−14.
How common The G allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 12, band 12q12 — in an intron of LRRK2.
What each result means
C/CNo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1491942 is a single position in the genome, in or near the LRRK2 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1491942 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1491942 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1491942 come from?
GWAS Catalog, Lancet 2011, PMID:21292315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 392215112223Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot1Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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