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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.187 higher (95% confidence interval 0.17-0.21); p = 2 × 10−78.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 16, band 16q13 — in an intron of CETP.
What each result means
C/CNo copy of the version the research linked to Haematocrit percentage (UKB data field 30030). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Haematocrit percentage (UKB data field 30030). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Haematocrit percentage (UKB data field 30030). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs148654654
What is rs148654654?
rs148654654 is a single position in the genome, in or near the CETP gene. Published research associates it with haematocrit percentage (ukb data field 30030). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs148654654 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs148654654 affect how medicines work?
CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs148654654 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs148654654 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Haematocrit percentage (UKB data field 30030) (rs148654654). MyGeneLog™. https://www.mygenelog.com/variants/rs148654654