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Free Cholesterol to Cholesteryl Esters in Very Large HDL ratio

near SLC30A10 · rs148468000

Where this position leads

Condition: Age-Related Macular Degeneration

rs148468000 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs148468000 rs148468000 near SLC30A10

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.721 higher (95% confidence interval 0.53-0.92); p = 2 × 10−13.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 1, band 1q41 — between genes, 21.4 kb from SLC30A10.

What each result means

A/A Two copies of the version the research linked to Free Cholesterol to Cholesteryl Esters in Very Large HDL ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Very Large HDL ratio. That is a smaller link than two copies.
G/G No copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Very Large HDL ratio. This is the starting point the study compared everyone against.
Source

Questions about rs148468000

What is rs148468000?

rs148468000 is a single position in the genome, in or near the near SLC30A10 gene. Published research associates it with free cholesterol to cholesteryl esters in very large hdl ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148468000 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs148468000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148468000 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Free Cholesterol to Cholesteryl Esters in Very Large HDL ratio (rs148468000). MyGeneLog™. https://www.mygenelog.com/variants/rs148468000

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