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Free Cholesterol to Cholesteryl Esters in Small HDL ratio

SLC23A2 · rs148146846

Where this position leads

Condition: Age-Related Macular Degeneration

rs148146846 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs148146846 rs148146846 SLC23A2

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.207 higher (95% confidence interval 0.14-0.27); p = 3 × 10−11.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 20, band 20p13 — in an intron of SLC23A2.

What each result means

A/A Two copies of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. That is a smaller link than two copies.
G/G No copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. This is the starting point the study compared everyone against.
Source

Questions about rs148146846

What is rs148146846?

rs148146846 is a single position in the genome, in or near the SLC23A2 gene. Published research associates it with free cholesterol to cholesteryl esters in small hdl ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148146846 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs148146846 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148146846 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Free Cholesterol to Cholesteryl Esters in Small HDL ratio (rs148146846). MyGeneLog™. https://www.mygenelog.com/variants/rs148146846

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