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Who was studied 148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.381 higher (95% confidence interval 0.32-0.45); p = 2 × 10−31.
How common The C allele had a frequency of about 99% in the people studied.
Where it sits Chromosome 5, band 5p15.2 — a missense change in ANKH.
What ClinVar records
ClassificationBenign/Likely benign for Chondrocalcinosis 2, Craniometaphyseal dysplasia, autosomal dominant, ANKH-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-05-01.
ClinVar record 351544NM_054027.6(ANKH):c.560G>A (p.Arg187Gln)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2020 · PMID 32541925 · open access
Questions about rs146886108
What is rs146886108?
rs146886108 is a single position in the genome, in or near the ANKH gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs146886108 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs146886108 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs146886108 come from?
GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs146886108). MyGeneLog™. https://www.mygenelog.com/variants/rs146886108