ZRANB3 · rs1465146591
Where this position leads
Condition: Type 2 Diabetes
What the study found
Who was studied 2,342 Sub-Saharan African ancestry cases, 2,889 Sub-Saharan African ancestry controls; replicated in 1,602 South African Zulu ancestry cases, 976 South African Zulu ancestry controls.
The effect Each copy of the A allele shifted the measure 0.652 lower (95% confidence interval 0.43-0.87); p = 7 × 10−9.
How common The A allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 2, band 2q21.3 — in an intron of ZRANB3.
rs1465146591 is a single position in the genome, in or near the ZRANB3 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2019, PMID:31324766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.