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Monocyte count

near IKZF1 · rs145532105

Where this position leads

Conditions: Monocyte Count, Blood Cell Counts

rs145532105 Condition: Monocyte Count Monocyte Count Condition Condition: Blood Cell Counts Blood Cell Counts Condition rs145532105 rs145532105 near IKZF1

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−23, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 234,690 European ancestry individuals; replicated in 100,494 European ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10−24.

How common The G allele had a frequency of about 98% in the people studied.

Where it sits Chromosome 7, band 7p12.2 — between genes, 0.3 kb from IKZF1.

What each result means

G/G Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/T No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
Source
Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia
Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
American journal of human genetics · 2021 · PMID 34469753

Questions about rs145532105

What is rs145532105?

rs145532105 is a single position in the genome, in or near the near IKZF1 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145532105 linked to?

On MyGeneLog this position is linked to Monocyte Count, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs145532105 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145532105 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Monocyte count (rs145532105). MyGeneLog™. https://www.mygenelog.com/variants/rs145532105

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