A/AThe more common amino acid (isoleucine) at this position. OPN1LW sits on the X chromosome, so a man has only one copy; a woman has two, one per X. This amino acid appeared in every exon-3 haplotype tested except the single most-myopic one in a 2022 study of 413 men of European ancestry.
A/GOne X chromosome carries each amino acid (a woman only, since this gene is on the X chromosome). This position is one of eight that combine into a haplotype — it was not tested on its own, and its effect depends on which amino acids sit at the other seven positions on the same gene copy.
G/GThe rarer amino acid (valine) at this position on both X chromosomes (a woman only). In the 2022 study, this amino acid appeared specifically in the haplotype with the most myopic average refraction (mean -3.14 diopters, versus +0.51 for the least myopic haplotype tested) — but as one of eight positions that combine into that haplotype, not as an isolated effect.
Myopia is diagnosed and corrected with a standard eye exam and refraction, not by genotype. No guideline changes based on this position.
rs145009674 is a single position in the genome, in or near the OPN1LW gene. Published research associates it with myopia (opn1lw exon-3 haplotype). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs145009674 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs145009674 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145009674 come from?
Neitz et al. 2022, Genes (Basel) — insight from OPN1LW gene haplotypes into the cause and prevention of myopia; 413 men of European ancestry. PMID 35741704. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.