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Who was studied 373,733 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 6.94 z score lower; p = 4 × 10−12.
How common The C allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.
What each result means
C/CTwo copies of the version the research linked to Experiencing mood swings. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Experiencing mood swings. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Experiencing mood swings. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs1440476
What is rs1440476?
rs1440476 is a single position in the genome, in or near the TCF4 gene. Published research associates it with experiencing mood swings. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1440476 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs1440476 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1440476 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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