Gene Knowledge Graph
UTC
Standard

Pulmonary congestion and hypostasis (PheCode 503)

SLCO1B1 · rs142957626

Where this position leads

Drugs: Statins, Ticagrelor

rs142957626 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs142957626 rs142957626 SLCO1B1

What the study found

Who was studied 720 African American or Afro-Caribbean cases, 119,025 African American or Afro-Caribbean controls, 2,161 European ancestry cases, 441,880 European ancestry controls, 232 Hispanic or Latin American cases, 58,997 Hispanic or Latin American controls.

The effect Each copy of the T allele shifted the measure 3.36 lower (95% confidence interval 3.34-3.38); p = 4 × 10−11.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Pulmonary congestion and hypostasis (PheCode 503) — no copies of the reported risk allele.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulmonary congestion and hypostasis (PheCode 503).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulmonary congestion and hypostasis (PheCode 503) compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs142957626

What is rs142957626?

rs142957626 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with pulmonary congestion and hypostasis (phecode 503). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs142957626 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs142957626 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs142957626 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary congestion and hypostasis (PheCode 503) (rs142957626). MyGeneLog™. https://www.mygenelog.com/variants/rs142957626

← See all variants