Gene Knowledge Graph
UTC
Standard

Intelligence (MTAG)

PURG · rs1421334

Where this position leads

Condition: Intelligence

rs1421334 Condition: Intelligence Intelligence Condition rs1421334 rs1421334 PURG

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intelligence (MTAG) compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intelligence (MTAG).
C/C Published research associates this genotype with typical/baseline likelihood of Intelligence (MTAG) — no copies of the reported risk allele.
Source
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies G, Deary IJ
Molecular psychiatry · 2019 · PMID 29326435 · open access

Questions about rs1421334

What is rs1421334?

rs1421334 is a single position in the genome, in or near the PURG gene. Published research associates it with intelligence (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1421334 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs1421334 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1421334 come from?

GWAS Catalog, Mol Psychiatry 2018, PMID:29326435. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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