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Monocyte count variance

near LINC00540 · rs142006702

Where this position leads

Condition: Monocyte Count

rs142006702 Condition: Monocyte Count Monocyte Count Condition rs142006702 rs142006702 near LINC005…

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 403,993 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 4.67 higher (95% confidence interval 3.19-6.15); p = 6 × 10−10.

Where it sits Chromosome 13, band 13q12.11 — between genes, 120.6 kb from LINC00540.

What each result means

A/A Two copies of the version the research linked to Monocyte count variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Monocyte count variance. That is a smaller link than two copies.
C/C No copy of the version the research linked to Monocyte count variance. This is the starting point the study compared everyone against.
Source
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction
Xiang R, Ben-Eghan C, Liu Y, Roberts D, Ritchie S, Lambert SA, Xu Y, Takeuchi F, Inouye M
Nature communications · 2025 · PMID 40335489 · open access

Questions about rs142006702

What is rs142006702?

rs142006702 is a single position in the genome, in or near the near LINC00540 gene. Published research associates it with monocyte count variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs142006702 linked to?

On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.

Does having rs142006702 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs142006702 come from?

GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Monocyte count variance (rs142006702). MyGeneLog™. https://www.mygenelog.com/variants/rs142006702

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