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Glaucoma (primary open-angle)

CDKN2B-AS1 · rs1412829

Where this position leads

Condition: Glaucoma

rs1412829 Condition: Glaucoma Glaucoma Condition rs1412829 rs1412829 CDKN2B-AS1

What the study found

Who was studied 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls.

The effect Each copy of the A allele carried 1.39 times the odds of Glaucoma (primary open-angle) (95% confidence interval 1.33-1.45); p = 1 × 10−27.

Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.

What each result means

A/A Two copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
G/G No copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
Source

Questions about rs1412829

What is rs1412829?

rs1412829 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1412829 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs1412829 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1412829 come from?

GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glaucoma (primary open-angle) (rs1412829). MyGeneLog™. https://www.mygenelog.com/variants/rs1412829

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