Standard

Myopia (age of diagnosis)

near ZIC3 · rs1344035

Where this position leads

Condition: Myopia

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Myopia (age of diagnosis) — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myopia (age of diagnosis).

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myopia (age of diagnosis) compared to the general population.

Source

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY

and 86 more — show all

Höhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Polašek O, Hayward C, Bencic G, Rudan I, Wilson JF, Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimäki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP Jr, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Pärssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW

CREAM Consortium · 23andMe Research Team · UK Biobank Eye and Vision Consortium

Nature genetics · 2018 · PMID 29808027 · open access

Questions about rs1344035

What is rs1344035?

rs1344035 is a single position in the genome, in or near the near ZIC3 gene. Published research associates it with myopia (age of diagnosis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1344035 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

Does having rs1344035 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1344035 come from?

GWAS Catalog, Nat Genet 2018, PMID:29808027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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