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Who was studied 725 European ancestry cases, 11,145 European ancestry controls; replicated in 363 European ancestry cases.
The effect
Each copy of the T allele carried 1.67 times the odds of Glaucoma (low intraocular pressure) (95% confidence interval -); p = 1 × 10−12.
Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.
What each result means
C/CNo copy of the version the research linked to Glaucoma (low intraocular pressure). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Glaucoma (low intraocular pressure). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (low intraocular pressure). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2016 · PMID 26752265 · open access
Questions about rs1333037
What is rs1333037?
rs1333037 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with glaucoma (low intraocular pressure). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1333037 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1333037 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1333037 come from?
GWAS Catalog, Nat Genet 2016, PMID:26752265. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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