near HLA-DQA1 · rs13191810
Where this position leads
Condition: Age-Related Macular Degeneration
Strength of the evidence
Its strongest genetic-study result is p = 10−25, with 43 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 98,316 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.00296 higher (95% confidence interval 0.0023-0.0036); p = 1 × 10−20.
How common The T allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 9.1 kb from HLA-DQA1.
How common each version is
CT
C 70.7% · T 29.3%
C 70.7% · T 29.3%
C 59.6% · T 40.4%
C 80.7% · T 19.3%
C 89.7% · T 10.3%
C 72.2% · T 27.8%
C 75.0% · T 25.0%
C 72.1% · T 27.9%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs13191810 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with phospholipids in very large vldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Phospholipids in very large VLDL (rs13191810). MyGeneLog™. https://www.mygenelog.com/variants/rs13191810