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Substance use disorder

near GBE1 · rs13092938

Where this position leads

Condition: Substance Use Disorder

rs13092938 Condition: Substance Use Disorder Substance Use Disorder Condition rs13092938 rs13092938 near GBE1

What the study found

Who was studied 1,458,999 European ancestry individuals, 240,296 African ancestry individuals, 58,370 mixed American ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 7 × 10−9.

Where it sits Chromosome 3, band 3p12.2 — between genes, 190.6 kb from GBE1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Substance use disorder compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Substance use disorder.
G/G Published research associates this genotype with typical/baseline likelihood of Substance use disorder — no copies of the reported risk allele.
Source
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Lai D, Zhang M, Green N, Abreu M, Schwantes-An TH, Parker CC, Zhang S, Jin F, Sun A, Zhang P, Edenberg HJ, Liu Y
and 1 more — show all
Foroud T
Molecular psychiatry · 2026 · PMID 41057643 · open access

Questions about rs13092938

What is rs13092938?

rs13092938 is a single position in the genome, in or near the near GBE1 gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13092938 linked to?

On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs13092938 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13092938 come from?

GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Substance use disorder (rs13092938). MyGeneLog™. https://www.mygenelog.com/variants/rs13092938

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