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Takes medication for Glaucoma?

CADM2 · rs13064817

Where this position leads

Condition: Glaucoma

rs13064817 Condition: Glaucoma Glaucoma Condition rs13064817 rs13064817 CADM2

What the study found

Who was studied 4,849 African American or Afro-Caribbean cases, 50,656 African American or Afro-Caribbean controls, 1,360 Hispanic or Latin American cases, 27,954 Hispanic or Latin American controls, 201 East Asian ancestry cases, 3,346 East Asian ancestry controls, 13,744 European ancestry cases, 301,924 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.093 higher (95% confidence interval 0.069-0.117); p = 3 × 10−16.

How common The G allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 3, band 3p12.1 — in an intron of CADM2.

What each result means

G/G Two copies of the version the research linked to Takes medication for Glaucoma?. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Takes medication for Glaucoma?. That is a smaller link than two copies.
T/T No copy of the version the research linked to Takes medication for Glaucoma?. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs13064817

What is rs13064817?

rs13064817 is a single position in the genome, in or near the CADM2 gene. Published research associates it with takes medication for glaucoma?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13064817 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs13064817 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13064817 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for Glaucoma? (rs13064817). MyGeneLog™. https://www.mygenelog.com/variants/rs13064817

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