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Depression

TCF4 · rs12967143

Where this position leads

Condition: Depression (Self-Reported Symptoms)

rs12967143 Condition: Depression (Self-Reported Symptoms) Depression (Self-Reported Symptoms) Condition rs12967143 rs12967143 TCF4

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
Source
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X
and 26 more — show all
Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA, Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM
23andMe Research Team · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nature neuroscience · 2019 · PMID 30718901

Questions about rs12967143

What is rs12967143?

rs12967143 is a single position in the genome, in or near the TCF4 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12967143 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs12967143 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12967143 come from?

GWAS Catalog, Nat Neurosci 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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