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Refractive error

TRPM1 · rs12898290

Where this position leads

Condition: Myopia

What the study found

Who was studied 1,495,159 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0207 SD unit lower (95% confidence interval 0.014-0.027); p = 8 × 10⁻¹¹.

How common The A allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 15, band 15q13.3 — a missense change in TRPM1.

What ClinVar records

Classification Benign for Congenital stationary night blindness 1C; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-02-03. ClinVar record 315490 NM_001252024.2(TRPM1):c.4560T>A (p.His1520Gln)

Classification Likely benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2024-06-28. ClinVar record 2757902 NM_001252024.2(TRPM1):c.4560T>C (p.His1520=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Refractive error. That is a smaller link than two copies.

T/T No copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction

Cheng FF, Liu X, Mi H, Wang L, Ma R, Guo Y, Sidorenko J, Jiang C, Islam T, Meguro A, Hikino K, Ishikawa Y

and 15 more — show all

Tang S, Li T, Chen R, Wang L, Mägi R, Metspalu A, Takeuchi M, Mizuki N, Choquet H, Jin ZB, Chen G, Zhou K, Terao C, Zeng J, Yang J

Estonian Biobank Research Team · 23andMe Research Team

Nature genetics · 2026 · PMID 42009823 · open access

Questions about rs12898290

What is rs12898290?

rs12898290 is a single position in the genome, in or near the TRPM1 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12898290 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

Does having rs12898290 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12898290 come from?

GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Refractive error (rs12898290). MyGeneLog™. https://www.mygenelog.com/variants/rs12898290

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