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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.00921 SD unit higher (95% confidence interval 0.0063-0.0122); p = 9 × 10−10.
How common The T allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 14, band 14q24.2 — in an intron of DPF3.
What each result means
C/CNo copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Refractive error. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs12896976
What is rs12896976?
rs12896976 is a single position in the genome, in or near the DPF3 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12896976 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12896976 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12896976 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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