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Who was studied 361,194 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.107 lower (95% confidence interval 0.094-0.12); p = 2 × 10−60.
Where it sits Chromosome 16, band 16q13 — in an intron of CETP.
What each result means
C/CNo copy of the version the research linked to High-density lipoprotein levels (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to High-density lipoprotein levels (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to High-density lipoprotein levels (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 36376304 · open access
Questions about rs12708983
What is rs12708983?
rs12708983 is a single position in the genome, in or near the CETP gene. Published research associates it with high-density lipoprotein levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs12708983 affect how medicines work?
CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs12708983 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12708983 come from?
GWAS Catalog, Nature communications 2022, PMID:36376304. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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