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Who was studied 6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls; replicated in 7,888 South Asian ancestry cases, 20,679 South Asian ancestry controls, 387 European ancestry cases, 2,092 European ancestry controls, 19,998 East Asian ancestry cases, 30,983 East Asian ancestry controls.
The effect
Each copy of the C allele carried 1.05 times the odds of Type 2 diabetes (95% confidence interval 1.04-1.07); p = 3 × 10−9.
How common The C allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 8, band 8p11.23 — between genes, 13.2 kb from RPL26P25.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2017 · PMID 28869590 · open access
Questions about rs12681990
What is rs12681990?
rs12681990 is a single position in the genome, in or near the KCNU1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12681990 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs12681990 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12681990 come from?
GWAS Catalog, Nat Genet 2017, PMID:28869590. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 21172236Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others6Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs12681990). MyGeneLog™. https://www.mygenelog.com/variants/rs12681990