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Who was studied 6,333 European ancestry cases, 15,056 European ancestry controls; replicated in 15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios.
The effect
Each copy of the T allele carried 1.23 times the odds of Crohn's disease (95% confidence interval 1.18-1.28); p = 1 × 10−20.
How common The T allele had a frequency of about 42% in the people studied.
Where it sits Chromosome 5, band 5q31.1 — in an intron of CARINH.
What each result means
G/GNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs12521868
What is rs12521868?
rs12521868 is a single position in the genome, in or near the IL3 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12521868 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs12521868?
Subjects that appear in the title or abstract of the same papers as this rsID include gut and food intolerance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs12521868 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12521868 come from?
GWAS Catalog, Nat Genet 2010, PMID:21102463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 5732539222227Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity3Meta AI9Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total57Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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