SLC6A19 · rs12513763
Where this position leads
Condition: Renal Cell Carcinoma
What the study found
Who was studied 5,313 East Asian ancestry cases, 96,912 East Asian ancestry controls, 25,890 European ancestry cases, 743,585 European ancestry controls, 897 African American cases, 3,109 African American controls, 1,612 Hispanic or Latin American cases, 2,180 Hispanic or Latin American controls.
The effect Each copy of the T allele carried 0.87 times the odds of Renal cell carcinoma (95% confidence interval 0.84-0.9); p = 3 × 10−13.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — in an intron of SLC6A19.
What ClinVar records
Classification
Benign for Neutral 1 amino acid transport defect; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-07-14.
ClinVar record 1185326 NM_001003841.3(SLC6A19):c.1539-67T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs12513763 is a single position in the genome, in or near the SLC6A19 gene. Published research associates it with renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2026, PMID:42000752. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Renal cell carcinoma (rs12513763). MyGeneLog™. https://www.mygenelog.com/variants/rs12513763