Gene Knowledge Graph
UTC
Standard

Intelligence (MTAG)

ENSG00000257640 · rs12465778

Where this position leads

Condition: Intelligence

rs12465778 Condition: Intelligence Intelligence Condition rs12465778 rs12465778 ENSG00000257…

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Intelligence (MTAG) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intelligence (MTAG).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intelligence (MTAG) compared to the general population.
Source
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies G, Deary IJ
Molecular psychiatry · 2019 · PMID 29326435 · open access

Questions about rs12465778

What is rs12465778?

rs12465778 is a single position in the genome, in or near the ENSG00000257640 gene. Published research associates it with intelligence (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12465778 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs12465778 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12465778 come from?

GWAS Catalog, Mol Psychiatry 2018, PMID:29326435. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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