2 17111239Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3Others9Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0115 SD unit higher (95% confidence interval 0.0079-0.0151); p = 6 × 10−10.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 12, band 12q13.3 — in an intron of MARS1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Refractive error compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Refractive error.
G/GPublished research associates this genotype with typical/baseline likelihood of Refractive error — no copies of the reported risk allele.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs12425095
What is rs12425095?
rs12425095 is a single position in the genome, in or near the MARS1 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12425095 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12425095 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12425095 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 17111239Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3Others9Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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