0 1512237Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others7Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0218 SD unit lower (95% confidence interval 0.015-0.028); p = 8 × 10−11.
How common The A allele had a frequency of about 95% in the people studied.
Where it sits Chromosome 1, band 1p33 — between genes, 46.2 kb from LINC01738.
What each result means
A/ATwo copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Refractive error. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs12405587
What is rs12405587?
rs12405587 is a single position in the genome, in or near the near TRABD2B gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12405587 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12405587 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12405587 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1512237Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others7Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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