Gene Knowledge Graph
UTC
Sensitive

Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease

SLCO1B1 · rs12317268

Where this position leads

Drugs: Statins, Ticagrelor

rs12317268 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs12317268 rs12317268 SLCO1B1

What the study found

Who was studied 3,412 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.441 higher (95% confidence interval 0.36-0.52); p = 5 × 10−29.

How common The G allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease compared to the general population.
Source
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, Uluvar B, Wuttke M, Cheng Y, Ekici AB, Gyimesi G, Karoly ED
and 20 more — show all
Kotsis F, Mielke J, Gomez MF, Yu B, Grams ME, Coresh J, Boerwinkle E, Köttgen M, Kronenberg F, Meiselbach H, Mohney RP, Akilesh S, Schmidts M, Hediger MA, Schultheiss UT, Eckardt KU, Oefner PJ, Sekula P, Li Y, Köttgen A
GCKD Investigators
Nature genetics · 2023 · PMID 37277652 · open access

Questions about rs12317268

What is rs12317268?

rs12317268 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs12317268 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs12317268 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12317268 come from?

GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease (rs12317268). MyGeneLog™. https://www.mygenelog.com/variants/rs12317268

← See all variants