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Fluid intelligence

near ZNF322 · rs12209891

Where this position leads

Condition: Intelligence

rs12209891 Condition: Intelligence Intelligence Condition rs12209891 rs12209891 near ZNF322

What the study found

Who was studied 182,798 British ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0206 higher; p = 2 × 10−9.

How common The C allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — between genes, 37.1 kb from GUSBP2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Fluid intelligence — no copies of the reported risk allele.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fluid intelligence.
C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fluid intelligence compared to the general population.
Source
Shared genetic architecture between the topology of brain white matter structural connectome and fluid intelligence
Dong X, Huang W, Chen HJ, Zhang Y, Liu B, Zhang D, Zhang Z, Ma G, Shu N
Communications biology · 2026 · PMID 42092107 · open access

Questions about rs12209891

What is rs12209891?

rs12209891 is a single position in the genome, in or near the near ZNF322 gene. Published research associates it with fluid intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12209891 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs12209891 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12209891 come from?

GWAS Catalog, Communications biology 2026, PMID:42092107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fluid intelligence (rs12209891). MyGeneLog™. https://www.mygenelog.com/variants/rs12209891

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