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Coronary artery disease

CETP · rs12149545

Where this position leads

Condition: Coronary Artery Disease

Drug: Statins

rs12149545 Condition: Coronary Artery Disease Coronary Artery Disease Condition Drug: Statins Statins Drug rs12149545 rs12149545 CETP

What the study found

Who was studied up to 122,733 cases, up to 424,528 controls.

The effect Each copy of the A allele shifted the measure 0.0374 lower (95% confidence interval 0.025-0.05); p = 1 × 10−9.

How common The A allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 16, band 16q13 — between genes, 2.7 kb from CETP.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Coronary artery disease compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Coronary artery disease.
G/G Published research associates this genotype with typical/baseline likelihood of Coronary artery disease — no copies of the reported risk allele.
Source
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease
van der Harst P, Verweij N
Circulation research · 2018 · PMID 29212778 · open access

Questions about rs12149545

What is rs12149545?

rs12149545 is a single position in the genome, in or near the CETP gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12149545 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does rs12149545 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs12149545 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12149545 come from?

GWAS Catalog, Circ Res 2017, PMID:29212778. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary artery disease (rs12149545). MyGeneLog™. https://www.mygenelog.com/variants/rs12149545

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